Isoxazolines have transformed parasite control in cats by offering broad-spectrum protection against both ectoparasites and endoparasites in a single topical formulation.
Today’s combination products go beyond fleas and ticks; they target heartworms, intestinal parasites, mites and even tapeworms, giving veterinarians a unified approach to preventive care.
Below is a simplified breakdown of the three major isoxazoline-containing combination preventives for cats and what sets each product apart.
1. NexGard COMBO (Boehringer Ingelheim)
Active Ingredients: Esafoxolaner, Eprinomectin, Praziquantel
Administration: Monthly topical; for cats ≥ 8 weeks old and ≥ 0.8 kg
Parasites on Label:
- Heartworms
- Roundworms
- Tapeworms
- Hookworms
- Fleas
- Ticks
Why It Stands Out:
- The only isoxazoline product for cats containing praziquantel, enabling tapeworm treatment in the same monthly dose.
- Effective against two hookworm species, expanding its GI protection profile.
2. Bravecto PLUS (Merck)
Active Ingredients: Fluralaner, Moxidectin
Administration: 2-month topical; for cats ≥ 6 months old and ≥ 1.2 kg
Parasites on Label:
- Heartworms
- Roundworms
- Hookworms
- Fleas
- Ticks
Why It Stands Out:
- Offers the longest-duration isoxazoline protection for cats, with 2 months of flea and tick control per dose.
- Strong option for owners who prefer infrequent dosing without compromising broad-spectrum coverage.
3. Revolution PLUS (Zoetis)
Active Ingredients: Selamectin, Sarolaner
Administration: Monthly topical; for cats ≥ 8 weeks old and ≥ 1.3 kg
Parasites on Label:
- Heartworms
- Roundworms
- Hookworms
- Ear mites
- Fleas
- Ticks
Why It Stands Out:
- Only isoxazoline product labeled for ear mites, making it a top choice for otic parasitism.
- Helps prevent transmission of Dipylidium caninum by killing fleas before they can transmit the tapeworm.
Clinical Perspective: Choosing the Right Product
When selecting a parasiticide for feline patients, veterinarians should consider the specific needs of the household and the patient’s risk profile.
- For full GI coverage including tapeworms: NexGard COMBO is unmatched.
- For long-interval flea/tick control: Bravecto PLUS offers unrivaled longevity.
- For ear mite cases or flea-tapeworm transmission risks: Revolution PLUS brings unique benefits.
Each of these products elevates feline preventive medicine by providing reliable, easy-to-administer, broad-spectrum protection that addresses both common and overlooked parasitic threats.
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