Is Mefenamic Acid Safe for Dogs?
By Dr. Geoff Carullo, DVM, FPCCP, DPCVSCA
Answer: No.
Mefenamic acid is not safe for dogs and should never be given unless specifically prescribed by a veterinarian — which in practice is extremely rare.
Mefenamic acid is a human non-steroidal anti-inflammatory drug (NSAID) commonly used for pain and menstrual cramps. In dogs, however, it can be highly toxic.
Dogs metabolize NSAIDs very differently from humans. Even a single human dose may result in serious harm, especially in small breeds, senior dogs, dehydrated patients, or those with kidney or liver disease.
Why mefenamic acid is dangerous for dogs
In canine patients, mefenamic acid may cause:
- Severe stomach irritation and ulceration
- Vomiting, sometimes with blood
- Bloody diarrhea
- Acute kidney failure
- Liver damage
- Neurologic signs in overdose cases
One of the most common and dangerous mistakes pet owners make is assuming that human pain relievers are interchangeable with veterinary medications. They are not. Many human NSAIDs — including mefenamic acid — are among the top causes of drug toxicity in dogs.
What should be used instead?
Dogs should only receive:
- Veterinary-approved pain medications
- Properly calculated doses
- Drugs prescribed after a clinical examination
Pain is often a symptom of an underlying disease. Masking it with the wrong medication can delay diagnosis and worsen the condition.
If a dog accidentally ingests mefenamic acid
- This is a medical emergency
- Do not wait for symptoms
- Do not give home remedies
- Bring the dog to the nearest veterinary clinic immediately
Bottom line
Mefenamic acid is unsafe for dogs. Human painkillers should never be used as substitutes for proper veterinary care.
Dr. Geoff Carullo is a Fellow and the current President of the Philippine College of Canine Practitioners.
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